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How long does Tramadol stay in your urine test?



Tramadol is a potent synthetic opioid analgesic drug used to treat moderate to severe aches. When you order Tramadol online, it is available under brand names such as Ultram, ConZip, Rybix, and Ryzolt. Knowing how long it stays in the body can help you understand the precautions, drugs you need to avoid, and possible overdose. There are some unique concerns with this drug being used on children, so it will be best to first discuss it with a medical professional.

Like Valium (Diazepam) and Xanax (Alprazolam), Tramadol is also classified as a Schedule IV drug in the USA. It means that it has a low potential for abuse and addiction, even at the recommended dose, though abuse and addiction are still possible.

Tramadol is not tested for a standard 5-panel and 10-panel drug test. However, it will show up in another testing of drugs for prescription pain medicines. It can be habit-forming, which means it can sometimes lead to dependence. It is more likely when you take this drug for a prolonged time or are not taken as prescribed.

How does Tramadol work?

Tramadol is the same as other prescription pain, including hydrocodone, codeine, or morphine. Like other opioids medication, it works by binding the pain receptors in the patient’s brain to block the pain signals. This medicine can give you other effects also.

Tramadol increases the effects of serotonin and norepinephrine, two necessary chemical messengers or neurotransmitter in the patient’s brain. They both play an essential role in pain perception.

The main aim of this medicine is to relieve pain to help your body function better in day-to-day life tasks. Pain drugs such as Tramadol do not fix what is causing you pain. Often, it does not take the pain away completely.

What is Tramadol used to treat?

Tramadol is an oral drug used to treat ongoing moderate to moderately severe pain. It is similar to opioid analgesics that work in the brain to change how your body responds to the pain.

It is a narcotic like a pain-relieving oral drug used to treat moderate to severe pain in adults. The extended-release form of this medicine is used as a treatment for mild to severe chronic pain when treatment is needed around the clock.

Tramadol must be recommended by a medical professional and is available by prescription only. When you order Tramadol online, make sure this drug is taken exactly as prescribed.

How long does it take for Tramadol to work?

When you order Tramadol online for pain, its pain-relieving effects start in about an hour. The pain effects reach their peak in about three hours and then taper off. So, the usual Tramadol doses are needed every four to six hours or as needed for pain. There are also extended-release versions of this drug available for once-daily dosing.

People taking this medicine should alert their medical professional about any issues from the use of this drug and unusual side effects or symptoms. Caution should be taken to ensure this medicine is taken exactly as recommended.

The risk of dependence on most opioid drugs is usually high. However, the risk of addiction to tramadol is never increased.

Does Tramadol come in different strengths and forms?

When you buy Tramadol online, you can get it in different forms and strengths, such as capsules and tablets. Outside the USA, it is also available as injections and drops. The infusion and drops with some types of pills and tablets are immediate forms of these drugs. They start working in 30 to 60 minutes, and their effects may wear off within four to six hours.

The immediate form of Tramadol comes in the dose of 50 mg to 100 mg. It is usually recommended for the short duration treatment of pain. On the other hand, the extended-release form of this medicine includes capsules and tablets. They start working, but their effects last up to 12 to 24 hours. During this duration, the drug is released gradually.

The extended form of Tramadol comes in the strengths between 100 mg to 300 mg. It is a type of medicine that is usually prescribed for chronic pain.

How long does Tramadol last in your body?

According to FDA, the half-life of Tramadol in your blood is about five to nine hours, and even longer in people who have been using multiple doses. The half-life is the duration that medicine takes half of its amount out from the body. The complete elimination takes about five to six times more than half-life.

Tramadol breaks down in the liver and gets excreted mainly through your kidneys in the urine. Approximately 30 percent of the amount is excreted unchanged, and the rest gets converted into multiple metabolites that are then excreted.

  • In blood test: You can detect Tramadol in a blood test most quickly after it has been taken, generally up to 48 hours after the last use.
  • In saliva test: This medicine is generally detectable in the urine for one to four days.
  • In the urine test: Tramadol can be easily detected in the urine for one to four days after the last use.
  • In hair test: It is detectable up to 90 days.

Keep one thing in mind that many essential medicines test, such as ten and 5-panel testing, cannot detect Tramadol. However, it can be possible to order a unique testing technique for prescription pain medicines, such as Tramadol.

What factors can affect the detection time of Tramadol?

Approximately 7 percent of people have poor metabolism for Tramadol due to reduced activity of isoenzyme of cytochrome. It takes a significantly long time for an individual of this population to break down this medicine and tricyclic antidepressants or other depressants.

As a result, they have the more active drugs in the bloodstream for a prolonged time. These people are at the risk of taking other medications that further reduce the activity of enzymes that break down this drug.


The tablet form of Tramadol gets absorbed slowly by your body and gets excreted more slowly than either injected form or drop form. In addition, several other factors can affect the detection time of Tramadol, such as:


Tramadol’s half-life is believed to be increased up to seven hours in an individual over age 75. Further, this medicine can reach higher concentrations in the bloodstream of people that belong to this age group. As a result, this medicine may stay in an elderly people’s body longer than in younger people.


Women and men often process medicines differently due to physiological differences. The peak concentration of Tramadol in females is about 12 times higher than in males. So, due to this reason, this medicine may stay in women’s bodies for longer than males.

Liver Enzyme activity

Your liver creates an enzyme known as CYP2D6 that plays an essential role in breaking the Tramadol. However, different individuals have different levels of CYP2D6 activity. About 7 percent of Caucasian people have this enzyme that is less active than usual as a recessive trait, and a medical professional refers to these people as poor metabolizers.

If you have a poor metabolism of this enzyme, Tramadol will take longer than expected to get eliminated from your body. Conversely, if the enzyme is more active than usual, you may be a rapid metabolizer. In such cases, this medicine may get cleared from your system more quickly than expected. A medical professional may perform a blood test to determine how active the enzyme is.

Organ’s function

Before Tramadol leaves your system, it is metabolized by the liver enzyme and processed through the kidneys. If either kidneys or liver is not correctly functioning, Tramadol and its metabolites may take more time than usual to be broken down by the body than they would in healthy kidney and liver function.

Dosage of medicines

The amount of Tramadol an individual takes can affect how long the medicine will remain in the body. Someone taking a heavy dose of this medicine will take longer to clear the drug than an individual taking a low dose.


Tramadol is a synthetic opioid that is recommended for pain after surgery and for other types of chronic aches. It can stay in your body for about 72 hours. The amount of time it takes to eliminate from the system can be affected by different factors such as metabolism, the way you take it, and dosage.

So, to reduce the risk of addiction, it is necessary to only take Tramadol for a short period and precisely as prescribed. Besides the risk of dependence, there are some other side effects such as changes in mood, fatigue, nausea, and constipation.

It is necessary to contact your medical professional if you have any confusion regarding Tramadol.


What does Tramadol look like?

If you are unable to identify the Tramadol pill, you should know that a 50 mg tablet is a white color capsule-shaped pill with a coating surrounding it. The capsule is imprinted with ULTRAM, regarding the brand name on one side and 0659 on the other.

How much Tramadol can I take?

For chronic pain

  • Adults: The initial recommended dose is 100 mg once a day. Your medical professional may increase the amount as needed but not above 300 mg per day.
  • Children of age 12 years and above: Your medical professional must determine the proper dose.

Tramadol and Hydrocodone

Hydrocodone and Tramadol are two different types of pain medications known as opioid analgesics. They are used for treating moderate to severe pain, such as long-term pain related to chronic conditions and cancer. They can also treat aches from surgery and injury.

Hydrocodone is usually recommended for severe chronic pain when nonopioid pain medicines, such as acetaminophen and ibuprofen, do not respond.

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